Description

2H-Cyclopenta[B]Furan-2-One, Hexahydro-4-(Hydroxymethyl)-5-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-, (3Ar,4S,5R,6As)- is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced organic synthesis. This compound is valued for its complex bicyclic structure and protected functional groups, which make it a critical building block for the construction of intricate pharmaceutical molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Asymmetric Synthesis: Utilized as a starting material or advanced intermediate in stereoselective reactions to introduce specific stereocenters into target molecules.
• Process Chemistry Development: Serves as a critical material for route scouting, optimization, and scale-up studies in pharmaceutical process R&D.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemicals, and other performance materials requiring high structural fidelity.
• Academic & Contract Research: Used in university laboratories and CROs (Contract Research Organizations) for methodological research and the synthesis of novel chemical entities.

Basic Information

Product Name	2H-Cyclopenta[B]Furan-2-One, Hexahydro-4-(Hydroxymethyl)-5-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-, (3Ar,4S,5R,6As)-
CAS No.	69222-61-3
Molecular Formula	C14H22O5
Molecular Weight	270.32 g/mol
Synonyms	(3aR,4S,5R,6aS)-Hexahydro-4-(hydroxymethyl)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-cyclopenta[b]furan-2-one; (3aR,4S,5R,6aS)-4-(Hydroxymethyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one; THP-protected lactone intermediate; Chiral bicyclic lactone derivative; Hexahydro-2H-cyclopenta[b]furan-2-one derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to verify identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Our quality management system supports the stringent requirements of cGMP (current Good Manufacturing Practice) for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere such as nitrogen or argon for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.