Description

(R)-2-[(3R,5S,6S)-3,5-Dimethyltetrahydro-2-Oxo-2H-Pyran-6-Yl]Propionic Acid is a high-purity, chiral organic compound characterized by its specific stereochemistry and lactone-derived structure. This compound matters as a sophisticated building block and key chiral intermediate in the synthesis of complex, biologically active molecules, where its defined stereocenters are critical for efficacy. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams developing advanced therapeutics, including potential antibiotics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for antibiotics and enzyme-targeted drugs.
• Asymmetric Synthesis: Used as a building block to introduce specific stereochemistry into more complex molecular architectures, leveraging its (R)-configured propionic acid side chain and defined ring system.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with potential therapeutic value.
• Process Chemistry Development: Acts as a starting material or intermediate in scaling up synthetic routes for candidate drugs under Good Manufacturing Practice (GMP) guidelines.
• Biochemical Research: May be utilized as a substrate or inhibitor in enzymatic studies due to its structural similarity to natural lactone-containing compounds.
• Fine Chemical Production: Incorporated into the synthesis of specialty chemicals requiring high stereochemical purity for applications in agrochemicals or advanced materials.

Basic Information

Product Name	(R)-2-[(3R,5S,6S)-3,5-Dimethyltetrahydro-2-Oxo-2H-Pyran-6-Yl]Propionic Acid
CAS No.	69056-12-8
Molecular Formula	C11H18O4
Molecular Weight	214.26 g/mol
Synonyms	(3R,5S,6S)-6-[(1R)-1-Carboxyethyl]-3,5-dimethyl-5,6-dihydro-2H-pyran-2-one; (6R)-6-[(1R)-1-Carboxyethyl]-3,5-dimethyl-5,6-dihydro-2H-pyran-2-one; (R)-2-[(3R,5S,6S)-3,5-Dimethyl-6-oxo-3,4,5,6-tetrahydro-2H-pyran-2-yl]propanoic acid; 69056-12-8; (R)-2-[(3R,5S,6S)-3,5-Dimethyltetrahydro-2-oxo-2H-pyran-6-yl]propanoic acid
EINECS	Contact for details

Quality Control

Our (R)-2-[(3R,5S,6S)-3,5-Dimethyltetrahydro-2-Oxo-2H-Pyran-6-Yl]Propionic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, to ensure it meets exacting standards for research and development use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed when not in use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.