Description

(4S)-6β-Bromo-4α-Chloro-5,6,7,7Aα-Tetrahydro-5,5-Dimethylbenzofuran-2(4H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined bicyclic structure. This compound is of critical importance for its role as a key chiral building block in the synthesis of complex organic molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral precursor in the multi-step synthesis of proprietary drug candidates and complex target molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities, particularly for central nervous system (CNS) or anti-infective targets.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective reactions due to its defined (4S) configuration, enabling the construction of enantiomerically pure compounds.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant scale for new drug development pipelines.
• Fine Chemical Production: Acts as a specialized building block for the manufacture of high-value, low-volume fine chemicals and custom synthesis projects.

Basic Information

Product Name	(4S)-6β-Bromo-4α-Chloro-5,6,7,7Aα-Tetrahydro-5,5-Dimethylbenzofuran-2(4H)-One
CAS No.	68612-44-2
Molecular Formula	C10H12BrClO2
Molecular Weight	279.56 g/mol
Synonyms	(4S)-6β-Bromo-4α-chloro-5,6,7,7aα-tetrahydro-5,5-dimethyl-2(4H)-benzofuranone; (4S)-6β-Bromo-4α-chloro-5,5-dimethyl-4,5,6,7-tetrahydro-2-benzofuranone; 6β-Bromo-4α-chloro-5,5-dimethyl-4,5,6,7-tetrahydro-2-benzofuranone, (4S)-; (4S)-6-Bromo-4-chloro-5,5-dimethyl-4,5,6,7-tetrahydro-1-benzofuran-2-one; 68612-44-2; Bromochloro dimethyl tetrahydro benzofuranone
EINECS	Contact for details

Quality Control

Our (4S)-6β-Bromo-4α-Chloro-5,6,7,7Aα-Tetrahydro-5,5-Dimethylbenzofuran-2(4H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for advanced pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for prolonged stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.