Description

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-Triazol-1-Ylmethyl)-1,3-Dioxolan-4-Ylmethyl Methanesulphonate CAS NO 67914-86-7 is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key synthetic precursor in the production of modern triazole-class antifungal agents, valued for its precise stereochemistry and reactivity. It is primarily required by manufacturers in the pharmaceutical and agrochemical sectors for the development of potent active ingredients.

Application

• Pharmaceutical Intermediate: Critical building block for synthesizing systemic triazole antifungal drugs such as fluconazole, itraconazole, and voriconazole.
• Agrochemical Synthesis: Used in the production of triazole-based fungicides for crop protection.
• Chemical Research & Development: Serves as a key chiral template in medicinal chemistry for exploring new bioactive molecules.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in regulated GMP processes for the commercial-scale production of antifungal APIs.
• Fine Chemical Production: Utilized in the synthesis of other complex, high-value specialty chemicals requiring a 1,2,4-triazole moiety.

Basic Information

Item	Details
Product Name	cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-Triazol-1-Ylmethyl)-1,3-Dioxolan-4-Ylmethyl Methanesulphonate
CAS No.	67914-86-7
Molecular Formula	C14H16Cl2N3O5S
Molecular Weight	409.27 g/mol
Synonyms	cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate; (2R,4S)- and (2S,4R)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate; Fluconazole Intermediate; UK-49,858 Intermediate; Methanesulfonic acid, [(2R,4S)- and (2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl ester
EINECS	Contact for details

Quality Control

Our cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-Triazol-1-Ylmethyl)-1,3-Dioxolan-4-Ylmethyl Methanesulphonate is manufactured under strict quality systems. It undergoes rigorous analytical testing to ensure compliance with pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request to support your regulatory and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (cis-isomer)
Related Substances (HPLC)	Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.