Description

2,3,3A,6,7,7A-Hexahydro-β,7A-Dimethyl-1-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-3A-[(Trimethylsilyl)Oxy]-1H-Indene-5-Propanoic Acid Methyl Ester is a sophisticated synthetic intermediate characterized by its complex, multi-functional molecular architecture. This compound is of significant commercial value for its role in advanced organic synthesis, particularly in constructing intricate molecular frameworks. It is primarily sought after by research institutions and pharmaceutical development teams engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and proprietary molecules.
• Organic Synthesis Research: Used in academic and industrial R&D for methodology development and the construction of challenging carbon skeletons.
• Natural Product Synthesis: Serves as a critical precursor in the total synthesis of complex natural products with potential biological activity.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for potential commercial production.
• Chiral Synthesis: The molecule's defined stereocenters make it valuable for the preparation of enantiomerically pure compounds.
• Protecting Group Chemistry: The tetrahydro-2H-pyran-2-yl (THP) and trimethylsilyl (TMS) groups are classic protecting groups, making this ester a useful reagent in complex synthetic sequences.

Basic Information

Product Name	2,3,3A,6,7,7A-Hexahydro-β,7A-Dimethyl-1-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-3A-[(Trimethylsilyl)Oxy]-1H-Indene-5-Propanoic Acid Methyl Ester
CAS No.	67884-43-9
Molecular Formula	C23H38O5Si
Molecular Weight	422.63 g/mol
Synonyms	Methyl 2,3,3a,6,7,7a-hexahydro-β,7a-dimethyl-1-[(tetrahydro-2H-pyran-2-yl)oxy]-3a-[(trimethylsilyl)oxy]-1H-indene-5-propanoate; 1H-Indene-5-propanoic acid, 2,3,3a,6,7,7a-hexahydro-β,7a-dimethyl-1-[(tetrahydro-2H-pyran-2-yl)oxy]-3a-[(trimethylsilyl)oxy]-, methyl ester; Methyl (3aR,7aS)-2,3,3a,6,7,7a-hexahydro-β,7a-dimethyl-1-[(tetrahydro-2H-pyran-2-yl)oxy]-3a-[(trimethylsilyl)oxy]-1H-indene-5-propanoate (stereoisomer); THP/TMS-protected indene propanoate methyl ester. Contact for additional aliases.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high purity, which is critical for sensitive synthetic applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.