Description

2-Hydroxy-4-(Trimethylsilyl)-3-Butynoic Acid Ethyl Ester is a specialized organosilicon building block featuring a protected hydroxyl group and a silyl-protected alkyne moiety. This unique bifunctional structure makes it a valuable intermediate for the synthesis of complex molecules, particularly in pharmaceutical and advanced material research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, agrochemical, and material science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of active pharmaceutical ingredients (APIs), especially those requiring silicon-containing or alkyne-functionalized scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactive functional groups for structural diversification.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, silicones, and advanced organic-inorganic hybrid materials.
• Click Chemistry: The protected alkyne group is amenable to copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of bioconjugation and polymer chemistry.
• Ligand and Catalyst Development: Utilized in the synthesis of novel chiral ligands or organometallic catalysts for asymmetric synthesis.
• Organic Synthesis Building Block: A versatile reagent for introducing both trimethylsilyl and ester-protected hydroxy acid functionalities into target molecules.

Basic Information

Product Name	2-Hydroxy-4-(Trimethylsilyl)-3-Butynoic Acid Ethyl Ester
CAS No.	66697-09-4
Molecular Formula	C9H16O3Si
Molecular Weight	200.31 g/mol
Synonyms	Ethyl 2-Hydroxy-4-(trimethylsilyl)-3-butynoate; 4-(Trimethylsilyl)-2-hydroxy-3-butynoic Acid Ethyl Ester; 2-Hydroxy-4-(trimethylsilyl)but-3-ynoic Acid Ethyl Ester; TMS-Protected Ethyl Propiolate Glycidate; Ethyl (Trimethylsilyl)ethynylglycidate
EINECS	Contact for details

Quality Control

Our production of 2-Hydroxy-4-(Trimethylsilyl)-3-Butynoic Acid Ethyl Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. All products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific batch results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.