Description

1-Cycloocten-5-Yne, (Z)- is a highly specialized, strained cyclic alkyne-alkene of significant interest in advanced synthetic chemistry. Its unique structure, featuring both an internal alkyne and a cis-alkene within an eight-membered ring, makes it a valuable and versatile building block for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science sectors for applications such as click chemistry, metal-catalyzed cycloadditions, and the synthesis of novel polymers.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex, bioactive molecules and potential drug candidates through cycloaddition and cross-coupling reactions.
• Agrochemical Research: Used in the development of novel active ingredients and fine chemicals with unique structural properties.
• Materials Science: Acts as a monomer or cross-linking agent in the creation of specialty polymers and advanced materials with tailored thermal or mechanical properties.
• Academic & Industrial R&D: A critical reagent for methodological development in organic synthesis, particularly in strain-promoted reactions and metal-organic chemistry.
• Click Chemistry Substrate: Its strained alkyne moiety is highly reactive in copper-free click chemistry applications, useful for bioconjugation and labeling.

Basic Information

Product Name	1-Cycloocten-5-Yne, (Z)-
CAS No.	66633-23-6
Molecular Formula	C8H8
Molecular Weight	104.15 g/mol
Synonyms	(Z)-1-Cycloocten-5-yne; (Z)-Cyclooct-1-en-5-yne; cis-1-Cycloocten-5-yne; 1,2,5,6-η-Cycloocten-5-yne; Bicyclo[6.2.0]deca-1,7,9-triene (related valence isomer); Strained cyclic enyne
EINECS	Contact for details

Quality Control

Every batch of 1-Cycloocten-5-Yne, (Z)- is produced and analyzed under strict quality protocols to ensure consistency and purity for research and development applications. Our standard grade typically meets a purity specification of ≥95% (by GC or HPLC), with identity confirmed by spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, identity, and impurity profile is provided with each shipment. Custom synthesis and higher purity grades are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized and highly volatile, this material should be stored under an inert atmosphere (e.g., nitrogen or argon) at recommended temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Keep away from heat, sparks, and open flame. Use only in a well-ventilated area or fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.