Description

1-Bromo-2-(Chloromethyl)-4-Methoxybenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional nature, featuring both bromo and chloromethyl substituents on a methoxybenzene scaffold, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those with complex aryl-alkyl ether or substituted benzylamine structures.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the methoxybenzene moiety is a core structural element.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers requiring specific halogenated aromatic units.
• Custom Chemical Synthesis: A valuable scaffold for contract research organizations (CROs) and fine chemical companies producing bespoke compounds for client projects.

Basic Information

Product Name	1-Bromo-2-(Chloromethyl)-4-Methoxybenzene
CAS No.	66192-25-4
Molecular Formula	C8H8BrClO
Molecular Weight	235.51 g/mol
Synonyms	2-Bromo-1-(chloromethyl)-4-methoxybenzene; 4-Methoxy-2-bromobenzyl chloride; 1-Bromo-2-chloromethyl-4-methoxybenzene; 2-Bromo-4-methoxybenzyl chloride; (2-Bromo-4-methoxyphenyl)methyl chloride; 4-Methoxy-α-bromo-o-tolyl chloride; Benzene, 1-bromo-2-(chloromethyl)-4-methoxy-
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-2-(Chloromethyl)-4-Methoxybenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.