Description

3-Phenylcyclobutanecarboxylic Acid is a versatile and synthetically valuable organic building block characterized by its unique cyclobutane ring fused with a phenyl substituent. This compound matters as a key chiral intermediate and scaffold in advanced pharmaceutical research and fine chemical synthesis, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry and as a precursor for specialty polymers.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides and fungicides, leveraging its rigid cyclobutane core.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specific thermal and mechanical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry, including ring-opening and functionalization reactions.

Basic Information

Product Name	3-Phenylcyclobutanecarboxylic Acid
CAS No.	66016-28-2
Molecular Formula	C11H12O2
Molecular Weight	176.21 g/mol
Synonyms	3-Phenylcyclobutanecarboxylic Acid; 3-Phenylcyclobutane-1-carboxylic Acid; Benzenebutanoic acid, β,γ-cyclo-; β,γ-Cyclobenzenebutanoic acid; Cyclobutane-1-carboxylic acid, 3-phenyl-; 1-Carboxy-3-phenylcyclobutane; 3-Phenyl-1-cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Phenylcyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay, chiral purity (if applicable), and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.