Description

Glabrescione B is a specialized natural product compound with significant interest in pharmaceutical and biochemical research. This compound matters as a potent and selective inhibitor of the Hedgehog signaling pathway, a critical target in oncology and developmental biology research. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in cancer research, drug discovery, and the study of cellular signaling mechanisms.

Application

• Pharmaceutical Research & Development: As a key reference standard and active investigational compound in cancer drug discovery programs.
• Biochemical Pathway Inhibition: Used in vitro and in vivo studies to specifically inhibit the Hedgehog (Hh) signaling pathway.
• Oncology Research: Investigation of its effects on various cancer cell lines, including those associated with basal cell carcinoma and medulloblastoma.
• Academic Research: A vital tool for universities and research institutes studying developmental biology, stem cell regulation, and tissue regeneration.
• High-Throughput Screening (HTS): Employed as a control or benchmark compound in screening assays designed to identify new Hedgehog pathway modulators.
• Mechanism of Action Studies: Elucidation of the molecular interactions and binding characteristics within the Hedgehog signaling cascade.

Basic Information

Product Name	Glabrescione B
CAS No.	65893-94-9
Molecular Formula	C25H28O4
Molecular Weight	392.49 g/mol
Synonyms	Glabrescione B; (E)-3-(3,4-Dihydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one; 1-(2,4,6-Trihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one; Hedgehog Pathway Inhibitor GBI; Natural Chalcone Derivative
EINECS	Contact for details

Quality Control

Our Glabrescione B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant standards for research-grade biochemicals to support reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.