Description

Lithium Iodoacetate is a versatile organolithium reagent and a key alkylating agent used in organic synthesis and biochemical research. Its primary value lies in its ability to introduce the iodoacetate functional group, a critical tool for modifying proteins and synthesizing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly for applications involving enzyme inhibition and peptide chemistry.

Application

• Biochemical Research: As a potent alkylating agent for the selective modification of cysteine residues in proteins and enzymes, facilitating structure-function studies.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of targeted drug candidates and active pharmaceutical ingredients (APIs).
• Proteomics & Enzyme Inhibition: Used to create irreversible enzyme inhibitors, aiding in the study of metabolic pathways and drug discovery.
• Organic Synthesis: Employed in carbon-carbon bond formation reactions and the preparation of complex organic molecules.
• Cross-linking Agent: Utilized in the preparation of modified biomaterials and for studying protein-protein interactions.
• Chemical Biology Probes: Acts as a precursor for developing activity-based probes to label and identify specific enzyme families.

Basic Information

Product Name	Lithium Iodoacetate
CAS No.	65749-30-6
Molecular Formula	C2H2IO2Li
Molecular Weight	191.89 g/mol
Synonyms	Lithium iodoacetate; Iodoacetic acid lithium salt; Acetic acid, iodo-, lithium salt; Lithium 2-iodoacetate; 2-Iodoacetic acid lithium salt; Iodoacetate lithium; Lithium monoiodoacetate
EINECS	Contact for details

Quality Control

Our Lithium Iodoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-purity standards suitable for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and easily oxidized nature. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.