Description

(S)-1-(Benzyloxycarbonyl)Hexahydropyridazine-3-Carboxylic Acid is a high-purity, chiral building block essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly for chiral drug candidates. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in peptide-mimetic chemistry, protease inhibitor development, and other sophisticated medicinal chemistry programs requiring high stereochemical purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, especially protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetic Research: Used to construct constrained peptide analogs and scaffolds that mimic natural peptide structures for enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tools for studying enzyme function and mechanism.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to introduce chirality into target molecules.
• API Development: Integral to the research and process development stages for new chemical entities (NCEs) in pre-clinical and clinical trials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP conditions.

Basic Information

Product Name	(S)-1-(Benzyloxycarbonyl)Hexahydropyridazine-3-Carboxylic Acid
CAS No.	65632-62-4
Molecular Formula	C13H16N2O4
Molecular Weight	264.28 g/mol
Synonyms	(S)-1-CBZ-Hexahydropyridazine-3-carboxylic Acid; (S)-1-(Benzyloxycarbonyl)perhydropyridazine-3-carboxylic Acid; (3S)-1-[(Benzyloxy)carbonyl]hexahydropyridazine-3-carboxylic Acid; (S)-1-Cbz-1,2,3,4,5,6-hexahydropyridazine-3-carboxylic Acid; Z-(S)-Hexahydropyridazine-3-carboxylic Acid; (S)-N-Cbz-Hexahydropyridazine-3-carboxylic Acid; (S)-1-(Benzyloxycarbonyl)-1,2,3,4,5,6-hexahydropyridazine-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (S)-1-(Benzyloxycarbonyl)Hexahydropyridazine-3-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and pharmaceutical applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), chiral purity (typically ≥99% ee), and impurity profile is provided with each shipment. We support development under cGMP guidelines for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.