Description

17-Hydroxycyproterone Acetate is a synthetic steroid derivative of cyproterone acetate, recognized for its potent antiandrogenic and progestogenic properties. This compound is a critical pharmaceutical intermediate and reference standard in the development and quality control of hormonal therapies. It is primarily required by pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in endocrinology, oncology, and dermatology. Its high purity and consistent quality are essential for ensuring the efficacy and safety of final drug products and research outcomes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced steroidal active pharmaceutical ingredients (APIs) with antiandrogenic activity.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of drug substances and finished products via HPLC, GC, or LC-MS.
• Biomedical Research: Employed in preclinical studies to investigate androgen receptor pathways, hormone-dependent cancers (e.g., prostate cancer), and conditions like hirsutism or acne.
• Active Pharmaceutical Ingredient (API): Serves as the core therapeutic agent in the formulation of prescription medications for hormonal disorders.
• Metabolite Studies: Used as an analytical standard to identify and quantify 17-hydroxycyproterone acetate and related metabolites in pharmacokinetic and bioequivalence studies.

Basic Information

Product Name	17-Hydroxycyproterone Acetate
CAS No.	65423-26-9
Molecular Formula	C₂₄H₂₉ClO₅
Molecular Weight	432.94 g/mol
Synonyms	17α-Hydroxy-6α-chloro-1,2α-methylenepregna-4,6-diene-3,20-dione 17-acetate; 6-Chloro-17α-hydroxy-1,2α-methylenepregna-4,6-diene-3,20-dione acetate; 17-Hydroxy-6-chloro-1,2-methylene-4,6-pregnadiene-3,20-dione 17-acetate; Cyproterone acetate 17-hydroxy metabolite; 17-OH-CPA
EINECS	Contact for details

Quality Control

Our 17-Hydroxycyproterone Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.