Description

L-Proline, 1-((5-Chloro-3,4-Dihydro-3-Methyl-1-Oxo-1H-2-Benzopyran-7-Y L)Carbonyl)-4-Hydroxy-, trans- is a specialized, high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. Its complex molecular architecture, featuring a proline moiety fused with a substituted isochromanone core, makes it a valuable building block for creating novel bioactive compounds. This product is primarily targeted at pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of potential therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the development of enzyme inhibitors, leveraging the proline scaffold for targeted biological activity.
• Medicinal Chemistry: Serves as a crucial precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Bioconjugation & Peptidomimetics: Employed in the design and synthesis of peptide analogs and bioconjugates to enhance stability and bioavailability.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	L-Proline, 1-((5-Chloro-3,4-Dihydro-3-Methyl-1-Oxo-1H-2-Benzopyran-7-Y L)Carbonyl)-4-Hydroxy-, trans-
CAS No.	64398-32-9
Molecular Formula	C16H16ClNO5
Molecular Weight	337.76 g/mol
Synonyms	(2S,4R)-1-[(5-Chloro-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-7-carbonyl)]-4-hydroxyproline; trans-4-Hydroxy-L-proline, 1-[(5-chloro-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-yl)carbonyl]-; 7-[[(2S,4R)-4-Hydroxy-2-pyrrolidinylcarbonyl]-5-chloro-3-methyl-3,4-dihydro-1H-2-benzopyran-1-one; L-Proline, 1-[(5-chloro-3,4-dihydro-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]-4-hydroxy-, (trans)-; A Benzo-Fused Proline Derivative
EINECS	Contact for details

Quality Control

Our L-Proline derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.