Description

Benzenepropanenitrile, α-Amino-α-Methyl- is a specialized chiral nitrile building block of significant interest in advanced organic synthesis. Its value lies in its bifunctional structure, incorporating both a reactive nitrile group and a sterically hindered α-amino center, enabling the construction of complex, non-natural amino acid derivatives and other pharmacophores. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of non-proteinogenic amino acids, peptidomimetics, and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators with chiral centers.
• Catalyst & Ligand Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, dyes, and advanced materials requiring specific stereochemistry.
• Academic & R&D: A valuable tool in organic chemistry research for methodology development and exploring new reaction pathways.

Basic Information

Product Name	Benzenepropanenitrile, α-Amino-α-Methyl-
CAS No.	64384-47-0
Molecular Formula	C₁₀H₁₂N₂
Molecular Weight	160.22 g/mol
Synonyms	2-Amino-2-methyl-3-phenylpropionitrile; α-Amino-α-methylbenzenepropanenitrile; 2-Methyl-2-amino-3-phenylpropionitrile; 3-Phenyl-2-(aminomethyl)butyronitrile; (RS)-2-Amino-2-methyl-3-phenylpropionitrile; (±)-2-Amino-2-methyl-3-phenylpropionitrile; DL-2-Amino-2-methyl-3-phenylpropionitrile; 2-Methyl-2-aminophenylpropionitrile
EINECS	Contact for details

Quality Control

Our Benzenepropanenitrile, α-Amino-α-Methyl- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.