Description

(S)-Pyrrolidine-1-Carbothioic Acid CAS NO 64369-68-2 is a high-purity chiral building block and ligand of significant importance in asymmetric synthesis and pharmaceutical research. Its value lies in its role as a versatile intermediate for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and advanced materials. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality chiral auxiliaries.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly those targeting neurological and metabolic disorders.
• Asymmetric Catalysis Ligand: Used as a precursor or component in chiral ligands for transition metal-catalyzed reactions, such as asymmetric hydrogenations and cross-couplings.
• Agrochemical Synthesis: Employed in the research and development of enantiomerically pure pesticides and herbicides.
• Peptidomimetics Research: Serves as a constrained proline analogue for designing and synthesizing peptide-based therapeutics and diagnostic agents.
• Material Science: Investigated for the development of chiral polymers and functionalized surfaces with specific stereochemical properties.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry within university and corporate research laboratories.

Basic Information

Product Name	(S)-Pyrrolidine-1-Carbothioic Acid
CAS No.	64369-68-2
Molecular Formula	C5H9NOS
Molecular Weight	131.20 g/mol
Synonyms	(S)-1-Pyrrolidinecarbothioic Acid; (S)-Pyrrolidine-1-thiocarboxylic Acid; (S)-1-Carbothioylpyrrolidine; (S)-Pyrrolidine-1-carbothioate; L-Pyrrolidine-1-carbothioic Acid; (S)-Proline Thioamide Derivative; 1-Pyrrolidinecarbothioic Acid, (S)-; (S)-Tetrahydro-1H-pyrrole-1-carbothioic Acid
EINECS	Contact for details

Quality Control

Our (S)-Pyrrolidine-1-Carbothioic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.