Description

m-Peg5-Tos CAS NO 62921-76-0 is a high-purity polyethylene glycol (PEG) derivative functionalized with a tosylate (p-toluenesulfonate) leaving group, designed for efficient conjugation and linker chemistry. This compound is critical for introducing hydrophilic PEG spacers into target molecules, enhancing solubility and modifying pharmacokinetic properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for drug discovery and polymer synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Bioconjugation Reagent: Used to attach PEG chains to peptides, proteins, or small molecules to improve solubility and stability.
• Polymer Chemistry: Acts as a functional initiator or monomer in the synthesis of tailored, functionalized PEG-based polymers and hydrogels.
• Linker for Prodrugs: Employed in the design of prodrug systems where a cleavable PEG linker is required for controlled drug release.
• Surface Modification: Facilitates the PEGylation of nanoparticles and surfaces to reduce immunogenicity and improve biocompatibility.
• Chemical Biology Tool: Provides a handle for introducing PEG spacers in probe and sensor development for biochemical assays.

Basic Information

Product Name	m-Peg5-Tos
CAS No.	62921-76-0
Molecular Formula	C20H34O9S
Molecular Weight	450.55 g/mol
Synonyms	m-PEG5-Tosylate; 2,5,8,11,14-Pentaoxapentadecan-15-yl 4-methylbenzenesulfonate; α-Methyl-ω-tosyl-pentaethylene glycol; PEG5 Monomethyl Ether Tosylate; 4-Methylbenzenesulfonic Acid 2,5,8,11,14-Pentaoxapentadec-15-yl Ester; mPEG5-OTs; Monomethoxy PEG5 Tosylate
EINECS	Contact for details

Quality Control

Our m-Peg5-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.