Description

3-Chloro-5-Fluoro-4-Methoxyaniline is a halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides a versatile scaffold for constructing complex molecules with tailored properties. This intermediate is primarily needed by the pharmaceutical and agrochemical industries for the development of active ingredients, as well as by research institutions engaged in material science and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Dye and Pigment Manufacturing: Serves as a diazo component for producing azo dyes and high-performance pigments with enhanced lightfastness.
• Material Science Research: Building block for organic semiconductors, liquid crystals, and other functional materials requiring specific electronic properties.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for creating complex biaryl structures.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of proprietary compounds and development candidates.

Basic Information

Product Name	3-Chloro-5-Fluoro-4-Methoxyaniline
CAS No.	62918-78-9
Molecular Formula	C7H7ClFNO
Molecular Weight	175.59 g/mol
Synonyms	4-Methoxy-3-chloro-5-fluoroaniline; 3-Chloro-5-fluoro-4-methoxybenzenamine; 5-Fluoro-3-chloro-p-anisidine; Benzenamine, 3-chloro-5-fluoro-4-methoxy-; 3-Chloro-5-fluoro-4-methoxyphenylamine; 3-Chloro-5-fluoro-4-aminoanisole; 4-Amino-2-chloro-6-fluoroanisole
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluoro-4-Methoxyaniline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and purity. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.