Description

Phenol, 4-Amino-2-Chloro-6-Fluoro- is a halogenated aniline derivative that serves as a versatile and high-value synthetic intermediate. Its unique substitution pattern makes it a critical building block for constructing complex molecules with specific electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Dye and Pigment Manufacturing: Serves as a starting material for producing specialized azo dyes and high-performance pigments.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and polymers with tailored optical or electronic properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for creating complex biaryl structures.

Basic Information

Product Name	Phenol, 4-Amino-2-Chloro-6-Fluoro-
CAS No.	62918-76-7
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	2-Chloro-6-fluoro-4-aminophenol; 4-Amino-2-chloro-6-fluorophenol; 2-Chloro-6-fluoro-1-hydroxy-4-aminobenzene; 4-Amino-2-chloro-6-fluorohydroxybenzene; 2-Chloro-6-fluoro-4-hydroxyaniline; 4-Hydroxy-3-chloro-5-fluoroaniline; ACFP (abbreviation); 62918-76-7 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of Phenol, 4-Amino-2-Chloro-6-Fluoro- is produced under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed and under dry conditions to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.