Description

1-Bromomethyl-3-Chloro-5-Methylbenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its dual functionality, providing reactive sites for nucleophilic substitution and metal-catalyzed cross-coupling reactions. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing substituted benzyl or diarylmethane motifs.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the chloromethyl and bromomethyl groups allow for further functionalization.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in homogeneous catalysis.
• Material Science Research: Employed in the creation of novel organic frameworks, polymers, and liquid crystals.
• Chemical Biology Probes: Useful for introducing reporter groups or affinity tags into biologically active molecules.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and Negishi couplings to form biaryl structures.

Basic Information

Product Name	1-Bromomethyl-3-Chloro-5-Methylbenzene
CAS No.	62358-81-0
Molecular Formula	C8H8BrCl
Molecular Weight	219.51 g/mol
Synonyms	3-Chloro-5-methylbenzyl bromide; (3-Chloro-5-methylphenyl)methyl bromide; 1-(Bromomethyl)-3-chloro-5-methylbenzene; α-Bromo-3-chloro-5-methyltoluene; 3-Chloro-α-bromo-5-xylene; 3-Chloro-5-methylbenzylbromide; 3-Chloro-5-methylbenzyl bromide; 3-Chloro-5-methylbenzyl bromide
EINECS	Contact for details

Quality Control

Our 1-Bromomethyl-3-Chloro-5-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Purity (HPLC/GC Area %)	≥ 98.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.