Description

Kryptofix 221D is a high-purity, non-ionic phase-transfer catalyst and complexing agent widely used in organic synthesis and radiopharmaceutical production. Its core value lies in its exceptional ability to facilitate reactions in biphasic systems and complex specific metal ions, significantly improving yields and reaction kinetics. This product is essential for researchers and manufacturers in the pharmaceutical, radiochemistry, and fine chemical industries who require reliable and efficient synthetic tools. The compound is commercially supplied under the identifier CAS NO 62002-40-8.

Application

• As a phase-transfer catalyst (PTC) in nucleophilic substitution reactions, particularly fluorination reactions using alkali metal fluorides (e.g., KF, CsF).
• Critical reagent in the synthesis of Fluorodeoxyglucose (FDG) for Positron Emission Tomography (PET) imaging, where it facilitates the nucleophilic fluorination step.
• Complexing agent for alkali and alkaline earth metal cations, enhancing the reactivity of associated anions in organic solvents.
• Facilitator in alkylation, esterification, and etherification reactions under mild conditions.
• Used in the preparation of specialty polymers and materials requiring controlled polymerization or modification steps.
• Research and development applications in novel synthetic methodologies within academic and industrial laboratories.

Basic Information

Product Name	Kryptofix 221D
CAS No.	62002-40-8
Molecular Formula	C₁₄H₃₂N₂O₄
Molecular Weight	292.42 g/mol
Synonyms	4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane; Kryptofix® 221; Kryptofix 2.2.1; K222; K-221; 1,10-Diaza-4,7,13,16,21,24-hexaoxabicyclo[8.8.8]hexacosane; Kryptand 221
EINECS	263-349-1

Quality Control

Our Kryptofix 221D is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding applications like radiopharmaceutical synthesis. Each lot undergoes comprehensive analytical testing, including HPLC assay, NMR identification, and residual solvent analysis. A detailed Certificate of Analysis (COA) providing full specifications and test results is supplied with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.