Description

(4S)-(-)-T-Butyldimethylsiloxy-2-Cyclopenten-1-One CAS NO 61305-36-0 is a high-value chiral building block and synthetic intermediate, specifically the (4S)-enantiomer of a protected cyclopentenone derivative. Its primary value lies in its role as a key precursor for the stereoselective synthesis of complex natural products and biologically active molecules, particularly in pharmaceutical research and development. This compound is essential for chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, enantiomerically pure intermediates for advanced asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of prostaglandins, prostacyclins, and other bioactive prostanoids.
• Asymmetric Synthesis: Used in stereocontrolled reactions, including Michael additions, aldol reactions, and cycloadditions, to construct complex molecular architectures.
• Natural Product Synthesis: Serves as a versatile building block in the total synthesis of terpenes, steroids, and other natural products with cyclopentane or cyclopentanone cores.
• Agrochemical Research: Employed in the development of novel, enantiomerically pure active ingredients for crop protection.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(4S)-(-)-T-Butyldimethylsiloxy-2-Cyclopenten-1-One
CAS No.	61305-36-0
Molecular Formula	C11H20O2Si
Molecular Weight	212.36 g/mol
Synonyms	(4S)-(-)-4-(tert-Butyldimethylsilyloxy)-2-cyclopenten-1-one; (4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-cyclopenten-1-one; (S)-4-(tert-Butyldimethylsiloxy)-2-cyclopenten-1-one; (S)-TBDPSO Cyclopentenone; (4S)-TBDMS-protected 4-hydroxy-2-cyclopentenone; (S)-(-)-4-(tert-Butyldimethylsilyloxy)-2-cyclopentenone; (4S)-4-(Tert-butyldimethylsilyloxy)cyclopent-2-en-1-one
EINECS	Contact for details

Quality Control

Our (4S)-(-)-T-Butyldimethylsiloxy-2-Cyclopenten-1-One is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for asymmetric synthesis. We provide comprehensive Certificates of Analysis (COA) for each batch, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC/GC), and identity confirmation. Our quality systems are designed to support cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.