Description

2-Cyclobuten-1-One, 3-Ethoxy-2,4,4-trifluoro- is a specialized fluorinated cyclobutenone derivative, a high-value building block in advanced organic synthesis. Its core value lies in its unique trifluoroethoxy-substituted cyclobutenone structure, which provides a reactive scaffold for constructing complex, fluorinated molecules with enhanced properties. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Used to develop novel fluorinated pesticides and herbicides, where the fluorine atoms improve metabolic stability and membrane permeability.
• Advanced Material Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique thermal and chemical resistance profiles.
• Fluorine Chemistry & Catalysis: A valuable reagent for studying new fluorination methodologies and as a ligand precursor in organometallic catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke fluorinated compounds for client-specific projects.

Basic Information

Product Name	2-Cyclobuten-1-One, 3-Ethoxy-2,4,4-trifluoro-
CAS No.	60838-94-0
Molecular Formula	C6H5F3O2
Molecular Weight	166.10 g/mol
Synonyms	3-Ethoxy-2,4,4-trifluorocyclobut-2-en-1-one; 2,4,4-Trifluoro-3-ethoxy-2-cyclobuten-1-one; 2-Cyclobuten-1-one, 3-ethoxy-2,4,4-trifluoro-; Trifluoroethoxycyclobutenone; 3-Ethoxy-2,4,4-trifluoro-1-cyclobuten-1-one; 2,4,4-Trifluoro-3-ethoxycyclobut-2-enone
EINECS	Contact for details

Quality Control

Every batch of 2-Cyclobuten-1-One, 3-Ethoxy-2,4,4-trifluoro- undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of cGMP and ISO 9001 standards for advanced chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature and sensitivity to strong alkali/fluoride conditions, keep the container tightly sealed when not in use and store away from incompatible materials. For long-term storage, consider using inert gas headspace (e.g., nitrogen or argon) to minimize degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.