Description

3-Bromo-5-Chlorothiophene-2-Carboxylic Acid is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific halogenated thiophene motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the thiophene core contributes to biological activity.
• Material Science Research: Serves as a monomer or building block for creating conjugated polymers and organic electronic materials like organic semiconductors and OLED components.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes, enzyme inhibitors, and labeled compounds for biochemical studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale GMP batches.

Basic Information

Product Name	3-Bromo-5-Chlorothiophene-2-Carboxylic Acid
CAS No.	60729-38-6
Molecular Formula	C5H2BrClO2S
Molecular Weight	241.49 g/mol
Synonyms	2-Thiophenecarboxylic acid, 3-bromo-5-chloro-; 3-Bromo-5-chloro-2-thiophenecarboxylic acid; 5-Chloro-3-bromothiophene-2-carboxylic acid; 3-Bromo-5-chlorothiophene-2-carboxylate; 3-Br-5-Cl-thiophene-2-COOH; 2-Carboxy-3-bromo-5-chlorothiophene; 3-Bromo-5-chloro-thiophene-2-carboxylic acid; 3-Bromo-5-chloro-2-thiophene carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Chlorothiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light) as indicated in its chemical properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.