Description

(E)-(4R,9S,11As)-4,9-Dihydroxy-6-Methyl-3,10-Dimethylene-3A,4,7,8,9,10,11,11A-Octahydro-3H-Cyclodeca[B]Furan-2-One is a complex sesquiterpene lactone derivative with a defined stereochemistry, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in its unique polycyclic furanone structure, which provides a versatile scaffold for constructing pharmacologically active molecules and natural product analogs. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require sophisticated intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel therapeutic agents, particularly in anti-inflammatory and anticancer drug candidates.
• Natural Product Synthesis: Core building block for the total or semi-synthesis of complex sesquiterpenoids and related natural products.
• Agrochemical Research: Intermediate in the development of new generation pesticides and herbicides with specific biological activity.
• Asymmetric Catalysis Substrate: Used in methodological studies to develop new stereoselective chemical transformations.
• Reference Standard: Serves as a high-purity analytical standard for quality control and research in analytical laboratories.
• Material Science Precursor: Potential starting material for the synthesis of specialized polymers or ligands with specific optical properties.

Basic Information

Item	Details
Product Name	(E)-(4R,9S,11As)-4,9-Dihydroxy-6-Methyl-3,10-Dimethylene-3A,4,7,8,9,10,11,11A-Octahydro-3H-Cyclodeca[B]Furan-2-One
CAS No.	60362-95-0
Molecular Formula	C15H20O4
Molecular Weight	264.32 g/mol
Synonyms	4,9-Dihydroxy-6-methyl-3,10-dimethylene-3a,4,7,8,9,10,11,11a-octahydro-3H-cyclodeca[b]furan-2-one; (4R,9S,11aR)-4,9-Dihydroxy-6-methyl-3,10-dimethylene-3a,4,7,8,9,10,11,11a-octahydro-3H-cyclodeca[b]furan-2-one; A sesquiterpene lactone derivative; Cyclodeca[b]furan-2-one, 4,9-dihydroxy-6-methyl-3,10-dimethylene-3a,4,7,8,9,10,11,11a-octahydro-, (3aR,4R,9S,11aR)-; (E)-Isomer of the specified lactone.
EINECS	Contact for details

Quality Control

Our (E)-(4R,9S,11As)-4,9-Dihydroxy-6-Methyl-3,10-Dimethylene-3A,4,7,8,9,10,11,11A-Octahydro-3H-Cyclodeca[B]Furan-2-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, strength, and composition. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.