Description

1',2'-Dihydrorotenone is a derivative of the natural compound rotenone, a well-known botanical insecticide. This hydrogenated form is of significant interest in biochemical and pharmacological research for its modified biological activity and as a key intermediate in synthetic chemistry. It is primarily utilized by research institutions and chemical manufacturers focused on developing novel agrochemicals, neurotoxins for study, and specialized fine chemicals.

Application

• Biochemical Research: Used as a reference standard and active agent in studies investigating mitochondrial complex I inhibition and cellular metabolism.
• Agrochemical Intermediate: Serves as a crucial synthetic precursor for developing next-generation, modified botanical insecticides and acaricides.
• Neuroscience Studies: Employed in laboratory models to induce Parkinsonian symptoms and study dopaminergic neuron degeneration.
• Pesticide Metabolism Studies: Acts as a metabolite or analog of rotenone for environmental fate and toxicology research.
• Fine Chemical Synthesis: A valuable building block for the preparation of more complex, structurally related compounds for various applications.

Basic Information

Product Name	1',2'-Dihydrorotenone
CAS No.	6659-45-6
Molecular Formula	C23H22O6
Molecular Weight	394.42 g/mol
Synonyms	Dihydrorotenone; 1,2-Dihydrorotenone; 6aβ,12aβ-1,2,6,6a,12,12a-Hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one; Rotenone, 1',2'-dihydro-; NSC 168111; (6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
EINECS	229-679-0

Quality Control

Our 1',2'-Dihydrorotenone is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.