Description

2-Hydroxy-2,2-Bis(4-Phenylphenyl)Acetic Acid is a specialized organic compound featuring a central acetic acid moiety flanked by two bulky biphenyl groups, which imparts unique steric and electronic properties. This structure makes it a valuable intermediate for synthesizing advanced materials and fine chemicals where precise molecular architecture is required. It is primarily sought after by research and development teams in the pharmaceutical and specialty chemical sectors for applications in ligand design, polymer modification, and as a building block for complex organic frameworks.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for non-steroidal anti-inflammatory drugs (NSAIDs) or other therapeutics requiring a sterically hindered carboxylic acid group.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis, where the bulky biphenyl groups can influence metal coordination and catalytic activity in asymmetric synthesis.
• Polymer Science: Acts as a monomer or chain modifier in the synthesis of high-performance polymers, such as polyesters or polyamides, to introduce rigidity and thermal stability.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, or metal-organic frameworks (MOFs) due to its conjugated aromatic system and functional handle.
• Fine Chemical Synthesis: Utilized as a building block for creating complex organic molecules in agrochemical and dye research.

Basic Information

Product Name	2-Hydroxy-2,2-Bis(4-Phenylphenyl)Acetic Acid
CAS No.	6334-91-4
Molecular Formula	C26H20O3
Molecular Weight	380.44 g/mol
Synonyms	α-Hydroxy-α,α-bis(4-biphenylyl)acetic acid; 2,2-Bis(4-phenylphenyl)-2-hydroxyacetic acid; 2-Hydroxy-2,2-di([1,1'-biphenyl]-4-yl)acetic acid; Diphenylacetic acid, α-hydroxy-α,α-bis(4-phenylphenyl)-; (4-Biphenylyl)phenylglycolic acid; α,α-Bis(4-phenylphenyl)glycolic acid; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-2,2-Bis(4-Phenylphenyl)Acetic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (by HPLC), related substances, and physical characteristics is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific customer or pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.