Description

3-Hydroxyquinuclidine-3-Carbonitrile is a versatile and highly functionalized bicyclic organic compound, serving as a critical chiral building block and intermediate in advanced chemical synthesis. Its unique structure, featuring both a hydroxyl group and a nitrile on the same carbon atom of the quinuclidine scaffold, makes it invaluable for constructing complex molecules with precise stereochemistry. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting neurological and cardiovascular diseases.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where its rigid bicyclic structure can impart specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Synthesis: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Academic & R&D: A valuable reagent for methodological studies in organic synthesis and for exploring new chemical transformations.

Basic Information

Product Name	3-Hydroxyquinuclidine-3-Carbonitrile
CAS No.	6238-30-8
Molecular Formula	C9H12N2O
Molecular Weight	164.21 g/mol
Synonyms	3-Hydroxyquinuclidine-3-carbonitrile; 3-Cyano-3-hydroxyquinuclidine; 1-Azabicyclo[2.2.2]octane-3-carbonitrile, 3-hydroxy-; 3-Hydroxy-1-azabicyclo[2.2.2]octane-3-carbonitrile; Quinuclidine-3-carbonitrile, 3-hydroxy-; 3-Hydroxyquinuclidine carbonitrile; (3-Hydroxyquinuclidin-3-yl)acetonitrile (tautomeric form)
EINECS	Contact for details

Quality Control

Our 3-Hydroxyquinuclidine-3-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC/GC purity, chiral purity (where applicable), and identification via spectroscopic methods (IR, NMR, MS). A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (if applicable)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.