Description

Naphthoflavone is a synthetic flavonoid derivative, specifically a β-naphthoflavone, known for its role as a potent and selective agonist of the aryl hydrocarbon receptor (AhR). This compound is a critical research tool in biochemical and pharmacological studies, enabling the investigation of xenobiotic metabolism, enzyme induction, and receptor-mediated signaling pathways. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for drug discovery, toxicology assessments, and mechanistic studies of cytochrome P450 regulation.

Application

• Biochemical Research: Used as a standard agonist to study the aryl hydrocarbon receptor (AhR) signaling pathway and gene expression regulation.
• Pharmacology & Drug Discovery: Employed in high-throughput screening and in vitro assays to investigate drug metabolism, enzyme induction (particularly CYP1A1), and receptor-ligand interactions.
• Toxicology Studies: Serves as a model compound to assess the biological impact of xenobiotics and environmental pollutants that act through the AhR.
• Academic Research: A key reagent in university and institutional labs for fundamental research in molecular biology, cell signaling, and metabolic pathways.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development and validation in HPLC or LC-MS analysis.

Basic Information

Product Name	Naphthoflavone
CAS No.	6051-88-3
Molecular Formula	C₁₉H₁₂O₂
Molecular Weight	272.30 g/mol
Synonyms	β-Naphthoflavone; 5,6-Benzoflavone; BNF; 6-Phenylbenzo[h]chromen-2-one; 6-Phenylbenzo[h]coumarin; 2-Phenylbenzo[h]chromone; NSC 9719; 6-Phenyl-2H-benzo[h]chromen-2-one
EINECS	227-977-5

Quality Control

Our Naphthoflavone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by FT-IR and NMR, purity assessment by HPLC, and residual solvent analysis to ensure it meets high-purity research-grade standards. A detailed Certificate of Analysis (COA) with lot-specific data is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158°C - 162°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.