Description

Diethyl L-Malate is a high-purity chiral ester derived from L-malic acid, serving as a critical building block in asymmetric synthesis. Its value lies in providing a readily available, enantiomerically pure template for constructing complex molecules with defined stereochemistry. This product is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise chiral control is paramount for product efficacy and safety.

Application

• Pharmaceutical Intermediates: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, anti-inflammatory, and cardiovascular drugs.
• Asymmetric Catalysis & Ligand Synthesis: Used as a precursor for chiral ligands and catalysts in enantioselective reactions, including hydrogenations and cross-couplings.
• Agrochemicals: Employed in the production of chiral pesticides and herbicides to enhance biological activity and reduce environmental impact.
• Flavor and Fragrance Industry: Acts as an intermediate for synthesizing specific, high-value aroma chemicals and flavor enhancers.
• Polymer Chemistry: Serves as a monomer or co-monomer for creating functionalized polymers with specific optical or physical properties.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and stereochemistry studies.

Basic Information

Product Name	Diethyl L-Malate
CAS No.	691-84-9
Molecular Formula	C8H14O5
Molecular Weight	190.19 g/mol
Synonyms	(S)-(-)-Diethyl Malate; L-(-)-Diethyl Malate; Diethyl (S)-(-)-Malate; Diethyl (2S)-2-Hydroxybutanedioate; (S)-Diethyl 2-Hydroxysuccinate; Ethyl L-Malate; L-Malic Acid Diethyl Ester; (-)-Diethyl Malate
EINECS	211-719-5

Quality Control

Our Diethyl L-Malate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]20/D	-15.0° to -18.0° (c=1 in ethanol)
Refractive Index n20/D	1.435 - 1.445
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.