Description

2,2,2-Trifluoro-N,n-Dimethylacetimidamide is a versatile fluorinated acetimidamide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique trifluoromethyl and amidine functional groups, which are instrumental in modulating the physicochemical properties of target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to introduce fluorine atoms and complex nitrogen-containing motifs.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting protease inhibitors, kinase inhibitors, and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for nitrogen-donor ligands in coordination chemistry and catalysis, enabling the development of new catalytic systems.
• Material Science Research: Employed in the synthesis of fluorinated polymers, dyes, and advanced organic materials with tailored electronic and surface properties.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological mechanisms and diagnostic applications.

Basic Information

Product Name	2,2,2-Trifluoro-N,n-Dimethylacetimidamide
CAS No.	684-09-3
Molecular Formula	C4H7F3N2
Molecular Weight	140.11 g/mol
Synonyms	N,N-Dimethyl-2,2,2-trifluoroacetimidamide; 2,2,2-Trifluoro-N,N-dimethylacetimidamide; Trifluoroacetamidine dimethyl acetal; 2,2,2-Trifluoro-N,N-dimethylacetamidine; TFAA-DMA; N,N-Dimethyltrifluoroacetamidine; (Dimethylamino)(trifluoromethyl)carbene imine
EINECS	211-683-5

Quality Control

Our production of 2,2,2-Trifluoro-N,n-Dimethylacetimidamide adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from strong acids and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.