Description

3-(Trifluoromethyl)Benzenesulfonamide is a versatile organosulfur compound featuring a sulfonamide group and a trifluoromethyl substituent on the benzene ring. This structure makes it a valuable intermediate and building block in advanced chemical synthesis, particularly for creating molecules with enhanced biological activity and specific physicochemical properties. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve compound stability and bioavailability.
• Material Science Precursor: Serves as a monomer or additive in the production of specialty polymers, coatings, and materials requiring specific surface properties or chemical resistance.
• Chemical Research & Development: Employed as a standard reagent in organic synthesis laboratories for sulfonylation reactions and the introduction of the trifluoromethylphenyl moiety.
• Ligand and Catalyst Development: Utilized in the design of novel ligands for metal catalysis and in the creation of organocatalysts for asymmetric synthesis.

Basic Information

Product Name	3-(Trifluoromethyl)Benzenesulfonamide
CAS No.	672-58-2
Molecular Formula	C7H6F3NO2S
Molecular Weight	225.19 g/mol
Synonyms	m-(Trifluoromethyl)benzenesulfonamide; α,α,α-Trifluoro-m-toluenesulfonamide; 3-Trifluoromethylphenylsulfonamide; Benzenesulfonamide, 3-(trifluoromethyl)-; m-Trifluoromethylphenylsulfonamide; 3-Carboxybenzenesulfonamide, 3-Trifluoromethyl-; 3-(Trifluoromethyl)benzene-1-sulfonamide
EINECS	211-595-5

Quality Control

Our 3-(Trifluoromethyl)Benzenesulfonamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 147 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.