Description

2,2,2-Trifluoro-1-Phenylethanone Oxime is a specialized fluorinated oxime compound that serves as a versatile building block in advanced organic synthesis. Its unique trifluoromethyl group adjacent to the oxime functionality makes it a critical intermediate for introducing fluorine atoms into target molecules, which is a key strategy in modern pharmaceutical and agrochemical design. This high-purity intermediate is essential for research chemists and process development scientists in the life sciences and material science sectors seeking to enhance the metabolic stability, bioavailability, and lipophilicity of novel compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of fluorinated active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, enhancing charge transport and thermal stability.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions for constructing complex fluorinated aromatic systems.
• Ligand & Catalyst Development: Utilized in the synthesis of novel chiral auxiliaries and catalysts for asymmetric synthesis.
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of PET (Positron Emission Tomography) imaging agents, though specific pathways require validation.

Basic Information

Product Name	2,2,2-Trifluoro-1-Phenylethanone Oxime
CAS No.	655-25-4
Molecular Formula	C8H6F3NO
Molecular Weight	189.13 g/mol
Synonyms	α,α,α-Trifluoroacetophenone Oxime; 2,2,2-Trifluoroacetophenone Oxime; Trifluoromethyl Phenyl Ketoxime; (E/Z)-2,2,2-Trifluoro-1-phenylethan-1-one oxime; 655-25-4; NSC 406908; F3C-C(=NOH)-Ph
EINECS	211-485-9

Quality Control

Our 2,2,2-Trifluoro-1-Phenylethanone Oxime is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	82 - 86 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Isomeric Ratio (E/Z)	Reported on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.