Description

(Z)-Bromofumaric Acid CAS NO 644-80-4 is a halogenated derivative of fumaric acid, serving as a versatile and reactive chemical building block in advanced organic synthesis. Its unique structure, featuring a bromine atom on the (Z)-configured alkene, makes it a critical intermediate for constructing complex molecules with high stereochemical control. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce bromine or fumarate motifs into target structures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring bromo-olefin or maleic acid derivative functional groups.
• Agrochemical Synthesis: Used in the research and production of herbicides, fungicides, and other crop protection agents where its reactive bromine enables further functionalization.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the development of specialty polymers, including those with functional handles for post-polymerization modification.
• Organic Synthesis Reagent: Employed in Michael addition reactions, cycloadditions, and as a precursor for other fine chemicals and complex organic compounds in R&D laboratories.
• Bioconjugation & Linker Chemistry: Useful for modifying biomolecules or creating cleavable linkers in drug delivery systems and diagnostic probes due to its electrophilic alkene.
• Material Science Research: Investigated for the preparation of organic electronic materials, metal-organic frameworks (MOFs), and other advanced functional materials.

Basic Information

Product Name	(Z)-Bromofumaric Acid
CAS No.	644-80-4
Molecular Formula	C4H3BrO4
Molecular Weight	194.97 g/mol
Synonyms	(Z)-2-Bromo-2-butenedioic Acid; (Z)-Bromobutenedioic Acid; (Z)-2-Bromofumaric Acid; Bromomaleic Acid (cis-isomer); cis-Bromofumaric Acid; (Z)-Bromomaleic Acid; 2-Bromo-(Z)-2-butenedioic Acid; Bromofumaric Acid (Z-isomer)
EINECS	211-433-5

Quality Control

Our (Z)-Bromofumaric Acid is produced and tested under a strict quality management system. Each batch undergoes comprehensive analysis to ensure high purity and consistency, meeting the stringent requirements for research and industrial synthesis. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (typically by HPLC), and impurity profile is provided with every shipment to guarantee reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as bases, oxidizing agents, and reducing agents. Ensure containers are kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.