Description

4-Bromo-2-Fluoroaniline is a halogenated aniline derivative that serves as a versatile and critical building block in advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents, makes it a valuable intermediate for introducing specific reactivity and electronic properties into target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Dye & Pigment Manufacturing: Employed in the synthesis of specialized halogenated dyes and colorants with improved lightfastness and chromatic properties.
• Cross-Coupling Reactions: Acts as a substrate in Buchwald-Hartwig amination, Suzuki, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl structures.
• Chemical Research & Development: Utilized in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	4-Bromo-2-Fluoroaniline
CAS No.	637-24-8
Molecular Formula	C6H5BrFN
Molecular Weight	190.01 g/mol
Synonyms	2-Fluoro-4-bromoaniline; 4-Bromo-2-fluoro-benzenamine; 1-Amino-4-bromo-2-fluorobenzene; Benzenamine, 4-bromo-2-fluoro-; 4-Bromo-2-fluoro-phenylamine; 4-Bromo-o-fluoroaniline; 2-Fluoro-4-bromo-phenylamine
EINECS	211-295-9

Quality Control

Our 4-Bromo-2-Fluoroaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong oxidizing agents and acids. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	30 - 34 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.