Description

D-Mannitol is a naturally occurring sugar alcohol (polyol) widely valued for its low hygroscopicity, pleasant sweetness, and excellent excipient properties. This versatile compound serves as a critical multi-functional ingredient in pharmaceutical formulations and a safe, reliable additive in the food industry. Key industrial sectors that rely on D-Mannitol CAS NO 69-65-8 include pharmaceutical manufacturing, food & beverage production, and chemical synthesis.

Application

• Pharmaceutical Excipient: Used as a non-hygroscopic diluent in tablet formulations, a sweetening agent in chewable tablets and lozenges, and a tonicity agent in parenteral solutions and diagnostic preparations.
• Food & Beverage Additive: Functions as a low-calorie sweetener, anti-caking agent, stabilizer, and texturizer in sugar-free confectionery, baked goods, and dietetic foods.
• Diagnostic Reagent: Employed in microbiology culture media and as a reagent in clinical biochemistry tests.
• Chemical Intermediate: Serves as a starting material or building block in organic synthesis for producing surfactants, resins, and other specialty chemicals.
• Personal Care & Cosmetics: Acts as a humectant and viscosity controller in oral care products, creams, and lotions.
• Industrial Applications: Used in the production of explosives (mannitol hexanitrate) and as a plasticizer in certain polymer systems.

Basic Information

Product Name	D-Mannitol
CAS No.	69-65-8
Molecular Formula	C6H14O6
Molecular Weight	182.17 g/mol
Synonyms	Mannitol; D-(-)-Mannitol; Mannite; Cordycepic acid; 1,2,3,4,5,6-Hexanehexol; (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol; Pearlitol® (common trade name); Mannogem™ (common trade name)
EINECS	200-711-8

Quality Control

Our D-Mannitol is manufactured under strict quality management systems. We offer various grades, including USP/EP, FCC, and industrial, each meeting stringent specifications for identity, purity, and performance. Every batch is supported by a comprehensive Certificate of Analysis (COA) to ensure compliance with relevant pharmacopeial (USP, Ph. Eur., JP) or food chemical codex (FCC) standards. Our quality commitment extends to full traceability and GMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Although D-Mannitol has low hygroscopicity, prolonged exposure to high humidity should be avoided to prevent caking.

Specification

Item	Specification
Appearance	White crystalline powder or free-flowing granules
Identification (IR)	Conforms
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Specific Rotation	[α]20/D: +23° to +25° (c=10 in H2O)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Reducing Sugars	≤ 0.3% (as glucose)
Chloride	≤ 0.007%
Sulfate	≤ 0.01%
Microbial Limits	Meets USP/EP requirements for specified grade

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.