Description

Benzamide, n-(cis-4-Aminocyclohexyl)-3,5-Difluoro- (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated benzamide structure attached to a cis-4-aminocyclohexyl moiety. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapies, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel small-molecule drug candidates, particularly kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation molecules.
• Chemical Biology Probes: Utilized in the development of selective chemical probes for studying specific biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.

Basic Information

Product Name	Benzamide, n-(cis-4-Aminocyclohexyl)-3,5-Difluoro- (9Ci)
CAS No.	589493-95-8
Molecular Formula	C13H16F2N2O
Molecular Weight	254.28 g/mol
Synonyms	N-(cis-4-Aminocyclohexyl)-3,5-difluorobenzamide; 3,5-Difluoro-N-(cis-4-aminocyclohexyl)benzamide; cis-4-[(3,5-Difluorobenzoyl)amino]cyclohexanamine; (cis)-4-Amino-N-(3,5-difluorophenyl)cyclohexanecarboxamide; Benzamide, N-(cis-4-aminocyclohexyl)-3,5-difluoro-; 589493-95-8; AKOS005258212
EINECS	Contact for details

Quality Control

Our Benzamide, n-(cis-4-Aminocyclohexyl)-3,5-Difluoro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with ICH Q7 guidelines for advanced intermediates, supporting regulatory filings for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.