Description

Ethyl 3-[6-Chloro-7-[(2-Chloro-6-Fluorophenyl)Methoxy]-4-Methyl-2-Oxochromen-3-Yl]Propanoate is a high-purity synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound, with CAS number 578698-22-3, is valued for its complex molecular architecture, which serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries working on new therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Serves as a key synthon for developing new-generation pesticides and herbicides with enhanced efficacy and selectivity.
• Chemical Biology Probe: Used in academic and industrial research to study enzyme inhibition and receptor-ligand interactions due to its specific structural motifs.
• Process Chemistry Development: Employed in route scouting and optimization studies for scalable API manufacturing processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	Ethyl 3-[6-Chloro-7-[(2-Chloro-6-Fluorophenyl)Methoxy]-4-Methyl-2-Oxochromen-3-Yl]Propanoate
CAS No.	578698-22-3
Molecular Formula	C22H19Cl2FO5
Molecular Weight	453.29 g/mol
Synonyms	Ethyl 3-(6-Chloro-7-((2-chloro-6-fluorobenzyl)oxy)-4-methyl-2-oxo-2H-chromen-3-yl)propanoate; 2H-1-Benzopyran-2-one, 3-[2-(ethoxycarbonyl)ethyl]-6-chloro-7-[(2-chloro-6-fluorophenyl)methoxy]-4-methyl-; 578698-22-3; Chromen-2-one derivative; Fluorinated coumarin ester intermediate.
EINECS	Contact for details

Quality Control

Every batch of Ethyl 3-[6-Chloro-7-[(2-Chloro-6-Fluorophenyl)Methoxy]-4-Methyl-2-Oxochromen-3-Yl]Propanoate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.