Description

6-Methyl-4-(Trifluoromethyl)-2,3-Dihydropyridazin-3-One is a high-value fluorinated heterocyclic building block, distinguished by its unique pyridazinone core and trifluoromethyl group which imparts significant metabolic stability and lipophilicity. This compound is critical for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring bioisosteric replacement. It serves as a key synthetic intermediate for pharmaceutical companies and advanced research institutions focused on agrochemicals and life sciences.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging the biological activity of the pyridazinone scaffold.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and for the introduction of the trifluoromethyl group to optimize potency and ADMET properties.
• Chemical Biology: Serves as a probe or precursor in the study of enzyme inhibition and biological pathway modulation.
• Material Science Precursor: Potential use in the synthesis of advanced organic materials and liquid crystals.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of targeted, high-complexity molecules for client projects.

Basic Information

Product Name	6-Methyl-4-(Trifluoromethyl)-2,3-Dihydropyridazin-3-One
CAS No.	560132-48-1
Molecular Formula	C7H5F3N2O
Molecular Weight	190.12 g/mol
Synonyms	4-(Trifluoromethyl)-6-methyl-2,3-dihydropyridazin-3-one; 6-Methyl-4-trifluoromethyl-2,3-dihydropyridazin-3-one; 3(2H)-Pyridazinone, 6-methyl-4-(trifluoromethyl)-; 560132-48-1; 4-Trifluoromethyl-6-methyl-3(2H)-pyridazinone; 6-Methyl-4-(trifluoromethyl)-3(2H)-pyridazinone
EINECS	Contact for details

Quality Control

Our 6-Methyl-4-(Trifluoromethyl)-2,3-Dihydropyridazin-3-One is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.