Description

2-Methyl-6-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is a high-value organosilicon triflate reagent, primarily used as a key intermediate in advanced organic synthesis. Its core value lies in its ability to act as a robust and selective leaving group, facilitating challenging cross-coupling and functional group transformations under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing sterically hindered biaryl systems.
• Catalyst & Ligand Synthesis: Used in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and polymerization reactions.
• Agrochemical Development: Serves as a key building block for novel herbicides, fungicides, and insecticides requiring specific silicon-containing motifs.
• Advanced Material Precursor: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional materials where the trimethylsilyl and triflate groups enable precise molecular engineering.
• Cross-Coupling Reactions: An excellent electrophile in Suzuki-Miyaura, Negishi, and related palladium-catalyzed cross-coupling reactions due to the high reactivity of the triflate group.
• Protecting Group Chemistry: The trimethylsilyl moiety can act as a protecting group for phenols or be utilized in subsequent silicon-based transformations.

Basic Information

Item	Detail
Product Name	2-Methyl-6-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate
CAS No.	556812-44-3
Molecular Formula	C11H15F3O3SSi
Molecular Weight	312.39 g/mol
Synonyms	2-Methyl-6-(trimethylsilyl)phenyl triflate; (2-Methyl-6-(trimethylsilyl)phenyl) trifluoromethanesulfonate; 2-Mesityl-6-(trimethylsilyl)phenyl triflate; 2-Methyl-6-trimethylsilylphenyl Triflate; o-Mesityltrimethylsilylphenyl Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid 2-Methyl-6-(trimethylsilyl)phenyl Ester
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-6-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is manufactured and tested under strict quality management systems. We guarantee high chemical purity and lot-to-lot consistency through comprehensive analytical techniques including NMR, HPLC, and GC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.