Description

2-Chloro-N-(4-difluoromethoxyphenyl)acetamide is a specialized organic intermediate of significant interest in advanced chemical synthesis. This compound matters for its role as a key building block in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoromethoxy and chloroacetamide functionalities are valuable. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific molecular motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, or insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Fine Chemical Production: Serves as a precursor for other complex specialty chemicals used in material science or as ligands in catalytic systems.
• Research & Development: Employed in academic and industrial R&D labs for method development, structure-activity relationship (SAR) studies, and exploring new chemical entities.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom intermediates for client-specific projects.

Basic Information

Product Name	2-Chloro-N-(4-difluoromethoxyphenyl)acetamide
CAS No.	554440-01-6
Molecular Formula	C9H8ClF2NO2
Molecular Weight	235.62 g/mol
Synonyms	2-Chloro-N-(4-(difluoromethoxy)phenyl)acetamide; N-(4-(Difluoromethoxy)phenyl)-2-chloroacetamide; Acetamide, 2-chloro-N-[4-(difluoromethoxy)phenyl]-; 2-Chloroacetamide, N-(4-difluoromethoxyphenyl)-; 4'-Difluoromethoxy-2-chloroacetanilide; 2-Chloro-4'-difluoromethoxyacetanilide; 554440-01-6; 2-Chloro-N-(4-difluoromethoxy-phenyl)-acetamide
EINECS	Contact for details

Quality Control

Our 2-Chloro-N-(4-difluoromethoxyphenyl)acetamide is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment. Store away from strong oxidizing agents, strong bases, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.