Description

cis-3-Hydroxycyclobutanecarboxylic Acid is a versatile chiral building block featuring a strained cyclobutane ring with both carboxylic acid and hydroxyl functional groups. This unique molecular architecture makes it a valuable synthon for constructing complex, conformationally constrained molecules in pharmaceutical and advanced material research. It is particularly sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise stereochemistry and rigid molecular scaffolds.

Application

• Pharmaceutical Intermediates: A key chiral precursor for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides where the cyclobutane ring can enhance biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a backbone for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers, contributing to materials with unique thermal and mechanical properties.
• Peptidomimetics and Bioisosteres: The constrained ring system is valuable for designing peptide mimics and bioisosteres in medicinal chemistry to improve metabolic stability and binding affinity.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	cis-3-Hydroxycyclobutanecarboxylic Acid
CAS No.	552849-33-9
Molecular Formula	C5H8O3
Molecular Weight	116.12 g/mol
Synonyms	(1r,3s)-3-Hydroxycyclobutanecarboxylic Acid; (1R,3S)-3-Hydroxycyclobutanecarboxylic Acid; cis-3-Hydroxy-1-cyclobutanecarboxylic Acid; (1R,3S)-3-Hydroxy-1-cyclobutanecarboxylic Acid; 3-Hydroxycyclobutanecarboxylic Acid, cis-; Cyclobutanecarboxylic acid, 3-hydroxy-, (1R,3S)-rel-; rel-(1R,3S)-3-Hydroxycyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our cis-3-Hydroxycyclobutanecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.