Description

2-Amino-5-(Trifluoromethoxy)Benzonitrile is a high-value, multi-functional aromatic nitrile building block featuring both an amino and a trifluoromethoxy substituent. This unique molecular structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals, where the trifluoromethoxy group is prized for its ability to modulate lipophilicity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and functional materials with specific electronic or surface properties.
• Fluorine Chemistry Studies: A valuable compound for research into the effects of fluorine and fluorinated alkoxy groups on chemical reactivity and physical properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Item	Detail
Product Name	2-Amino-5-(Trifluoromethoxy)Benzonitrile
CAS No.	549488-77-9
Molecular Formula	C8H5F3N2O
Molecular Weight	202.14 g/mol
Synonyms	2-Amino-α,α,α-trifluoro-p-anisonitrile; 5-(Trifluoromethoxy)anthranilonitrile; 2-Cyano-4-(trifluoromethoxy)aniline; 4-Amino-3-cyano-1-(trifluoromethoxy)benzene; 2-Amino-5-(trifluoromethoxy)benzonitrile; 5-Amino-2-(trifluoromethoxy)benzonitrile (isomer check); AN-698/40938035; BBL013937
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-5-(Trifluoromethoxy)Benzonitrile is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and consistency for your critical R&D and scale-up work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.