Description

Ethanone, 1-[(1R,3S)-3-(Hydroxymethyl)-2,2-Dimethylcyclobutyl]- (9Ci) is a high-purity chiral building block featuring a cyclobutane ring core with a hydroxymethyl substituent. This compound is valued for its defined stereochemistry and functional group versatility, making it a critical intermediate in advanced synthetic pathways. It is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, particularly in areas requiring stereochemically defined cyclobutane scaffolds.
• Asymmetric Synthesis: Used as a building block in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore novel chemical space.
• Fine Chemical Production: Serves as a precursor in the multi-step synthesis of specialty chemicals, flavors, and fragrances.
• Academic & Industrial R&D: Utilized in methodological development and the synthesis of novel organic compounds for material science and chemical biology applications.

Basic Information

Product Name	Ethanone, 1-[(1R,3S)-3-(Hydroxymethyl)-2,2-Dimethylcyclobutyl]- (9Ci)
CAS No.	528560-17-0
Molecular Formula	C9H16O2
Molecular Weight	156.22 g/mol
Synonyms	(1R,3S)-3-(Hydroxymethyl)-2,2-dimethylcyclobutyl methyl ketone; 1-[(1R,3S)-3-(Hydroxymethyl)-2,2-dimethylcyclobutyl]ethanone; (1R,3S)-2,2-Dimethyl-3-(hydroxymethyl)cyclobutyl methyl ketone; (1R,3S)-3-(Acetylmethyl)-2,2-dimethylcyclobutanol (tautomeric form); Chiral Cyclobutane Ketone; (1R,3S)-CBK derivative
EINECS	Contact for details

Quality Control

Our production of Ethanone, 1-[(1R,3S)-3-(Hydroxymethyl)-2,2-Dimethylcyclobutyl]- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. All material is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.