Description

(1R,2S)-2-Amino-4-Methylidene-Cyclopentane-1-Carboxylic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a unique cyclopentane scaffold with an exocyclic methylene group. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide mimetics, and specialized chemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, peptidomimetics, and other bioactive molecules targeting neurological and metabolic diseases.
• Peptide Chemistry: Used in solid-phase peptide synthesis (SPPS) to incorporate constrained, non-natural amino acids, enhancing peptide stability and biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing focused libraries in drug discovery programs, particularly for structure-activity relationship (SAR) studies.
• Chemical Biology: Employed in the design and synthesis of activity-based probes (ABPs) and molecular tools for studying enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Acts as a precursor or auxiliary in catalytic asymmetric reactions to introduce chirality into target molecules.

Basic Information

Product Name	(1R,2S)-2-Amino-4-Methylidene-Cyclopentane-1-Carboxylic Acid
CAS No.	526194-96-7
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	(1R,2S)-2-Amino-4-methylenecyclopentane-1-carboxylic acid; (1R,2S)-2-Amino-4-methylidenecyclopentanecarboxylic acid; 4-Methylidene-(1R,2S)-2-aminocyclopentane-1-carboxylic acid; (1R,2S)-AMCPC; (1R,2S)-2-Amino-4-methylidene-1-cyclopentanecarboxylic acid; (1R,2S)-4-Methylene-2-aminocyclopentanecarboxylic acid; (1R,2S)-2-Amino-4-methylidenecyclopentane carboxylic acid
EINECS	Contact for details

Quality Control

Our (1R,2S)-2-Amino-4-Methylidene-Cyclopentane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.