Description

4-Cyano-3-Fluorophenylzinc Bromide is a highly reactive organozinc reagent, specifically a functionalized arylzinc halide, essential for modern cross-coupling chemistry. Its core value lies in enabling the efficient, selective introduction of the valuable 4-cyano-3-fluorophenyl moiety into complex molecular architectures, a transformation critical for fine-tuning material and pharmaceutical properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and nitrile-substituted aromatic systems.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorinated cyano-phenyl group imparts specific biological activity and metabolic stability.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers requiring precise electronic and steric properties.
• Cross-Coupling Reactions: Serves as a superior nucleophile in Negishi, Kumada, and related palladium or nickel-catalyzed cross-couplings with various electrophiles.
• Ligand and Catalyst Preparation: Useful for synthesizing complex, functionalized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry: A valuable reagent for introducing fluorine-containing aromatic groups into target molecules in medicinal and materials chemistry.

Basic Information

Item	Detail
Product Name	4-Cyano-3-Fluorophenylzinc Bromide
CAS No.	521093-90-3
Molecular Formula	C7H4BrFNZn
Molecular Weight	259.41 g/mol
Synonyms	(4-Cyano-3-fluorophenyl)zinc bromide; 3-Fluoro-4-cyanophenylzinc bromide; Zinc, bromo(4-cyano-3-fluorophenyl)-; 4-Cyano-3-fluorobenzenezinc bromide; 521093-90-3; (3-Fluoro-4-cyanophenyl)zinc bromide; Bromo(4-cyano-3-fluorophenyl)zinc
EINECS	Contact for details

Quality Control

Our 4-Cyano-3-Fluorophenylzinc Bromide is produced under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including titration for active zinc content and spectroscopic methods to confirm structure and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C to minimize decomposition and maintain reactivity. Due to its highly volatile and easily oxidized nature, the reagent should be handled in a controlled, moisture-free environment and used promptly after opening.

Specification

Item	Specification
Appearance	Solution (typically in THF or ether)
Concentration	0.5 M in THF (or as specified)
Assay (by Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Purity (GC/HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.