Description

tert-Butyl 4-Cyano-Tetrahydro-2H-Pyran-4-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its unique bicyclic structure incorporating both a carbamate and a nitrile functional group. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of complex, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Serves as a key scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Protease Inhibitor Synthesis: Used in the development of inhibitors targeting specific enzymes, leveraging its carbamate moiety.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development and exploratory synthetic chemistry.

Basic Information

Product Name	tert-Butyl 4-Cyano-Tetrahydro-2H-Pyran-4-Ylcarbamate
CAS No.	519031-87-9
Molecular Formula	C11H18N2O3
Molecular Weight	226.27 g/mol
Synonyms	4-Cyano-tetrahydro-2H-pyran-4-carboxylic acid tert-butylamide; tert-Butyl 4-cyano-4-piperidinecarboxylate (related structural analog); 4-Cyano-THP-4-carbamic acid tert-butyl ester; 1-Boc-4-cyano-4-hydroxypiperidine derivative; BOC-4-Cyano-4-hydroxy-piperidine; 4-Cyano-1-N-Boc-piperidin-4-ol; tert-Butyl N-(4-cyanooxan-4-yl)carbamate; 519031-87-9
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-Cyano-Tetrahydro-2H-Pyran-4-Ylcarbamate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high chemical purity. Quality is verified against comprehensive specifications using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment, supporting cGMP-compliant workflows for our pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.