Description

4-Chloro-2-Fluorophenylzinc Iodide is a versatile organozinc reagent, a critical building block for the formation of carbon-carbon bonds in advanced organic synthesis. Its value lies in its ability to introduce the 4-chloro-2-fluorophenyl moiety with high selectivity and functional group tolerance under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing halogenated aromatic rings in drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require specific halogen-substituted phenyl groups.
• Cross-Coupling Reactions: A crucial partner in Negishi, Kumada, and other transition-metal catalyzed cross-coupling reactions to form biaryl structures.
• Ligand and Material Precursor: Serves as a building block for creating specialized ligands for catalysis and monomers for high-performance polymers.
• Chemical Research & Development: Enables exploratory synthesis in academic and industrial R&D labs for novel compound libraries and material discovery.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fine chemicals and specialty dyes.

Basic Information

Product Name	4-Chloro-2-Fluorophenylzinc Iodide
CAS No.	518989-99-6
Molecular Formula	C6H3ClFZnI
Molecular Weight	328.34 g/mol
Synonyms	Zinc, (4-chloro-2-fluorophenyl)iodo-; (4-Chloro-2-fluorophenyl)iodozinc; 4-Chloro-2-fluorophenylzinc iodide solution; 2-Fluoro-4-chlorophenylzinc iodide; Iodo(4-chloro-2-fluorophenyl)zinc; 4-Chloro-2-fluoro-1-iodozinc benzene
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluorophenylzinc Iodide is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes rigorous analytical testing, including titration for active zinc content and GC/HPLC analysis for purity and solvent composition. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light will degrade the reagent. Keep the container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in THF (typical, other solvents available)
Assay (Titration)	≥ 95%
Purity (GC/HPLC)	≥ 98% (relative area)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.