Description

2,4-Difluorophenylzinc Bromide is a highly reactive organozinc reagent, specifically an arylzinc halide, used in modern synthetic organic chemistry. Its value lies in its ability to act as a versatile nucleophile for the efficient introduction of the 2,4-difluorophenyl group into complex molecular frameworks via cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing new active ingredients, particularly where the difluorophenyl moiety is a critical pharmacophore or structural element.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the construction of active pharmaceutical ingredients (APIs) containing the 2,4-difluorophenyl group, often found in antifungal, anti-inflammatory, and central nervous system (CNS) drugs.
• Agrochemical Active Ingredient Development: Used in the research and production of advanced herbicides, fungicides, and insecticides where fluorinated aromatic rings enhance biological activity and environmental stability.
• Material Science & OLED Chemistry: Serves as a precursor in the synthesis of fluorinated organic semiconductors, liquid crystals, and light-emitting materials for electronic displays.
• Negishi Cross-Coupling Reactions: Functions as a superior coupling partner with various aryl, heteroaryl, and vinyl halides/pseudohalides, offering excellent functional group tolerance and selectivity.
• Catalytic Cycle Research: Employed in methodological studies to develop new palladium, nickel, or other transition metal-catalyzed coupling protocols.
• Ligand and Catalyst Synthesis: Used to prepare sophisticated, fluorinated ligands for asymmetric catalysis and organometallic complexes.

Basic Information

Product Name	2,4-Difluorophenylzinc Bromide
CAS No.	517920-79-5
Molecular Formula	C6H3F2ZnBr
Molecular Weight	258.29 g/mol
Synonyms	Bromo(2,4-difluorophenyl)zinc; Zinc, bromo(2,4-difluorophenyl)-; (2,4-Difluorophenyl)zinc bromide; 2,4-Difluorophenylzinc bromide solution; 1-Bromo-2,4-difluorobenzene zinc reagent; 2,4-DFP-ZnBr
EINECS	Contact for details

Quality Control

Our 2,4-Difluorophenylzinc Bromide is manufactured under strict quality-controlled conditions, typically supplied as a solution in tetrahydrofuran (THF) or other suitable solvents. Each batch undergoes rigorous analytical testing to ensure consistency and reactivity. Certificates of Analysis (COA) are provided, detailing parameters such as concentration (by titration), residual halide content, and solvent purity. We adhere to cGMP principles where applicable for pharmaceutical customers, ensuring traceability and documentation for regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For optimal stability, store under an inert atmosphere (argon or nitrogen) at recommended cold temperatures, typically between 2°C and 8°C. Keep the container tightly sealed in a dry, well-ventilated place. Observe all local regulations for the storage of pyrophoric and moisture-sensitive organometallic reagents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (Typical)	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95%
Identification (NMR)	Conforms to structure
Residual Bromide (IC)	Reported on COA
Solvent (GC)	Meets specified grade (e.g., anhydrous)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.