Description

2-Iodo-1,3-Phenylene Bis(Trifluoromethanesulfonate) is a high-value, multi-functional aryl iodide building block extensively used in advanced organic synthesis. Its core value lies in the combination of a highly reactive iodoarene group with two robust triflate leaving groups, enabling sequential and selective cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing complex molecules, ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor for constructing complex biaryl and heterobiaryl scaffolds via Suzuki-Miyaura, Stille, and other palladium-catalyzed cross-coupling reactions.
• Ligand Synthesis: Used in the preparation of sophisticated polydentate ligands for catalysis and metal-organic frameworks (MOFs).
• Agrochemical Development: Serves as a building block for novel active ingredients requiring specific halogenated aromatic cores.
• Functional Material Precursor: Enables the synthesis of conjugated polymers and organic electronic materials through sequential coupling strategies.
• Chemical Biology Probes: Facilitates the site-specific labeling of biomolecules via click chemistry or other bioorthogonal reactions.
• Diversification Library Synthesis: Ideal for parallel and combinatorial chemistry to rapidly generate arrays of structurally diverse compounds from a single, versatile intermediate.

Basic Information

Product Name	2-Iodo-1,3-Phenylene Bis(Trifluoromethanesulfonate)
CAS No.	514826-78-9
Molecular Formula	C8H3F6IO6S2
Molecular Weight	507.13 g/mol
Synonyms	1,3-Bis(trifluoromethanesulfonyloxy)-2-iodobenzene; 2-Iodobenzene-1,3-diyl bis(trifluoromethanesulfonate); 2-Iodoresorcinol bis(triflate); 1,3-Di(triflyloxy)-2-iodobenzene; 2-Iodo-m-phenylene bis(triflate); 2-Iodoresorcinol ditriflate; m-Phenylene bis(trifluoromethanesulfonate) iodide derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and high purity, which is critical for sensitive cross-coupling reactions. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request for every batch shipped.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity during use. Ideal storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.